A metallo pro-drug to target Cu(II) in the context of Alzheimer's disease - Peptides, glycoconjugués et métaux en biologie
Article Dans Une Revue Chemistry - A European Journal Année : 2018

A metallo pro-drug to target Cu(II) in the context of Alzheimer's disease

Résumé

Alzheimer's disease and oxidative stress are connected. In the present communication, we report the use of a Mn(II)-based superoxide dismutase mimic ([MnII(L)]+, 1+) as a pro-drug candidate to target Cu(II) associated events, i.e. Cu(II)-induced formation of reactive oxygen species (ROS) and modulation of the amyloid-beta (Aβ) peptide aggregation. Complex 1+ is able to remove Cu(II) from Aβ, stop ROS and prevent alteration of Aβ aggregation as would do the corresponding free ligand LH. Using 1+ instead of LH in further biological applications would have the double advantage to avoid the cell toxicity of LH and to benefit from its proved SOD-like activity.
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hal-01685637 , version 1 (18-01-2018)

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Amandine Conte-Daban, Vinita Ambike, Régis Guillot, Nicolas Delsuc, Clotilde Policar, et al.. A metallo pro-drug to target Cu(II) in the context of Alzheimer's disease. Chemistry - A European Journal, 2018, 24 (20), pp.5095-5099. ⟨10.1002/chem.201706049⟩. ⟨hal-01685637⟩
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