Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins - Peptides, glycoconjugués et métaux en biologie
Article Dans Une Revue Chemical Science Année : 2018

Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins

Marie Masuda
  • Fonction : Auteur
Takayuki Miki
  • Fonction : Auteur
Itaru Hamachi
  • Fonction : Auteur
Kadda Medjoubi
Andrea Somogyi

Résumé

Bio-imaging techniques alternative to fluorescence microscopy are gaining increasing interest as complementary tools to visualize and analyze biological systems. Among them, X-ray fluorescence microspectroscopy provides information on the local content and distribution of heavy elements (Z ≥ 14) in cells or biological samples. In this context, similar tools to those developed for fluorescence microscopy are desired, including chemical probes or tags. In this work, we study rhenium complexes as a convenient and sensitive probe for X-ray fluorescence microspectroscopy. We demonstrate their ability to label and sense exogenously incubated or endogenous proteins inside cells.
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Dates et versions

hal-01905965 , version 1 (26-10-2018)

Identifiants

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Sarah Hostachy, Marie Masuda, Takayuki Miki, Itaru Hamachi, Sandrine Sagan, et al.. Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins. Chemical Science, 2018, 9 (19), pp.4483-4487. ⟨10.1039/C8SC00886H⟩. ⟨hal-01905965⟩
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