An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase - Peptides, glycoconjugués et métaux en biologie
Article Dans Une Revue Chemical Communications Année : 2020

An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase

Philippe Seksik

Résumé

A combinatorial approach using a One-Bead-One-Compound method and a screening based on an SOD-activity assay was set up for the discovery of an efficient peptidyl copper complex. The complex exhibited good stability constants, suitable redox potentials and excellent intrinsic activity. This complex was further assayed in cells for its antioxidant properties and showed beneficial effect when cells were submitted to oxidative stress.
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Dates et versions

hal-02378888 , version 1 (25-11-2019)

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Amandine Vincent, Jennifer Rodon Fores, Elodie Tauziet, Elodie Quévrain, Ágnes Dancs, et al.. An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase. Chemical Communications, 2020, 56, pp.399-402. ⟨10.1039/C9CC07920C⟩. ⟨hal-02378888⟩
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