Gramicidin‐S‐Inspired Cyclopeptidomimetics as Potent Membrane‐Active Bactericidal Agents with Therapeutic Potential - Structure et Dynamique des Biomolécules
Article Dans Une Revue ChemMedChem Année : 2021

Gramicidin‐S‐Inspired Cyclopeptidomimetics as Potent Membrane‐Active Bactericidal Agents with Therapeutic Potential

Résumé

Antimicrobial peptides (AMPs) are promising antibacterial agents often hindered by their undesired hemolytic activity. Inspired by gramicidin S (GS), a well-known cyclodecapeptide, we synthesized a panel of antibacterial cyclopeptidomimetics using β,γ-diamino acids (β,γ-DiAAs). We observed that peptidomimetic CP-2 displays a bactericidal activity similar to that of GS while possessing lower side-effects. Moreover, extensive studies revealed that CP-2 likely kills bacteria through membrane disruption. Altogether, CP-2 is a promising membrane-active antibiotic with therapeutic potential

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hal-03988662 , version 1 (14-02-2023)

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Chengfei Hu, Quan Wen, Shuhui Huang, Saisai Xie, Yuanying Fang, et al.. Gramicidin‐S‐Inspired Cyclopeptidomimetics as Potent Membrane‐Active Bactericidal Agents with Therapeutic Potential. ChemMedChem, 2021, 16 (2), pp.368-376. ⟨10.1002/cmdc.202000568⟩. ⟨hal-03988662⟩
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