Improved Synthesis and Preparation of Analogues of a Pain-Relieving Pyridin-2(1H)-one - Neuro-Dol
Article Dans Une Revue Synthesis: Journal of Synthetic Organic Chemistry Année : 2024

Improved Synthesis and Preparation of Analogues of a Pain-Relieving Pyridin-2(1H)-one

Théo Frazier
Francis Giraud
Alain Artola
Radhouane Dallel
Fabrice Anizon
Pascale Moreau

Résumé

An optimization of the synthesis of 3,5-disubstituted pyridin-2(1H)-ones with in vivo anti-allodynic activity was conducted. The optimized synthesis was employed to prepare novel analogues which were then assessed for their efficacy in preventing cutaneous mechanical allodynia in a male rat hindpaw capsaicin model.
Fichier principal
Vignette du fichier
Synthesis Théo 2024-clean.pdf (707.32 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04741759 , version 1 (17-10-2024)

Identifiants

Citer

Théo Frazier, Pauline Murail, Francis Giraud, Alain Artola, Radhouane Dallel, et al.. Improved Synthesis and Preparation of Analogues of a Pain-Relieving Pyridin-2(1H)-one. Synthesis: Journal of Synthetic Organic Chemistry, 2024, 56 (13), pp.2093-2099. ⟨10.1055/s-0043-1763758⟩. ⟨hal-04741759⟩
0 Consultations
0 Téléchargements

Altmetric

Partager

More