Pathophysiology and management of enteric hyperoxaluria - Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation
Article Dans Une Revue Clinics and Research in Hepatology and Gastroenterology Année : 2024

Pathophysiology and management of enteric hyperoxaluria

Résumé

Enteric hyperoxaluria is a metabolic disorder resulting from conditions associated with fatty acid malabsorption and characterized by an increased urinary output of oxalate. Oxalate is excessively absorbed in the gut and then excreted in urine where it forms calcium oxalate crystals, inducing kidney stones formation and crystalline nephropathies. Enteric hyperoxaluria is probably underdiagnosed and may silently damage kidney function of patients affected by bowel diseases. Moreover, the prevalence of enteric hyperoxaluria has increased because of the development of bariatric surgical procedures. Therapeutic options are based on the treatment of the underlying disease, limitation of oxalate intakes, increase in calcium salts intakes but also increase in urine volume and correction of hypocitraturia. There are few data regarding the natural evolution of kidney stone events and chronic kidney disease in these patients, and there is a need for new treatments limiting kidney injury by calcium oxalate crystallization.
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hal-04589878 , version 1 (18-06-2024)

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Jordan Desenclos, Valentine Forté, Cécile Clément, Michel Daudon, Emmanuel Letavernier. Pathophysiology and management of enteric hyperoxaluria. Clinics and Research in Hepatology and Gastroenterology, 2024, 48 (5), pp.102322. ⟨10.1016/j.clinre.2024.102322⟩. ⟨hal-04589878⟩
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