A translational study for biomarker identification of PEP-010, a pro-apoptotic peptide restoring apoptosis in cancer models - Université de Paris - Faculté de Santé
Article Dans Une Revue (Data Paper) Biochimica et Biophysica Acta - Molecular Basis of Disease Année : 2025

A translational study for biomarker identification of PEP-010, a pro-apoptotic peptide restoring apoptosis in cancer models

Résumé

PEP-010 is a pro-apoptotic peptide based on a proprietary cell-penetrating and interfering peptide technology for the treatment of advanced solid tumors.

• PEP-010 acts by disrupting the interaction between caspase-9 and PP2A, two key proteins involved in apoptosis, a physiological process frequently altered in cancers. • PEP-010 efficiently induces apoptosis in cancer cells.

• PEP-010 demonstrates antitumor activity by inhibiting the growth of breast cancer patient-derived xenografts (PDX). • This study establishes cleaved caspase-3 and Ki67 protein expression as two candidate pharmacodynamic (PD) biomarkers for monitoring PEP-010-induced apoptosis in vitro and in vivo.

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hal-04740800 , version 1 (17-10-2024)

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D. Germini, R. Farhat, L. Dadon, A. Lacroix, F. Nemati, et al.. A translational study for biomarker identification of PEP-010, a pro-apoptotic peptide restoring apoptosis in cancer models. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025, 1871 (1), pp.167492. ⟨10.1016/j.bbadis.2024.167492⟩. ⟨hal-04740800⟩
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