Opioid-Induced Inter-regional Dysconnectivity Correlates with Analgesia in Awake Mouse Brains - Université de Paris - Faculté de Santé
Pré-Publication, Document De Travail Année : 2024

Opioid-Induced Inter-regional Dysconnectivity Correlates with Analgesia in Awake Mouse Brains

Jean-Charles Mariani
  • Fonction : Auteur
Samual Diebolt
  • Fonction : Auteur
Laurianne Beynac
  • Fonction : Auteur
Stefan Schulz
  • Fonction : Auteur
Thomas Deffieux
  • Fonction : Auteur
Mickael Tanter
  • Fonction : Auteur
Zsolt Lenkei
Andrea Kliewer
  • Fonction : Auteur
  • PersonId : 1429018

Résumé

The mu-opioid receptor (MOP) is crucial for both the therapeutic and addictive effects of opioids. Using a multimodal experimental approach, here we combined awake functional ultrasound (fUS) imaging with behavioral and molecular assessments, to examine opioid-induced changes in brain activation and functional connectivity (FC). Morphine, fentanyl, and methadone induce significant dose- and time-dependent reorganization of brain perfusion, oscillations and FC in awake mice. Notably, opioids induce a transient, region-specific hyperperfusion, followed by a consistent MOP-specific dysconnectivity marked by decreased FC of the somatosensory cortex to hippocampal and thalamic regions, alongside increased subcortical and intra-cortical FC. These FC changes temporally correlate with generalized brain MOP activation and analgesia, but not with hypermobility and respiratory depression, suggesting a reorganization of inter-regional FC as a key opioid effect.
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Dates et versions

hal-04741407 , version 1 (17-10-2024)

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Jean-Charles Mariani, Samual Diebolt, Laurianne Beynac, Renata Santos, Stefan Schulz, et al.. Opioid-Induced Inter-regional Dysconnectivity Correlates with Analgesia in Awake Mouse Brains. 2024. ⟨hal-04741407⟩

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